ABSTRACT This study is dedicated to the study of the effect of changes in the active energy of the parathyroid glands on the morphological tension of bone tissue formation. Experimental modeling of hypoparathyroidism in laboratory rats (n = 30) was carried out and the dynamics of morphological changes in the process of bone tissue ossification was analyzed. On the basis of the results of morphological methods of study, the dynamics of the formation of tubular bones was revealed, and the patterns of ossification of bone tissue against the background of hypoparathyroidism were also set. As a result of the study, it was shown that it differs from the usual histological picture of hypoparathyroid individuals in the zones of elevation, just the basal layer of chondrocytes are vacuolated. The emergence of young osteoblasts is oriented by the spaces; they are located according to the type of multidirectional architectonics.