Abstract Background: Pandemic Outbreak is an epidemic which is spread over multiple countries or continents. There were many pandemic outbreaks in the past centuries. Many pandemics have still not yet been identified and cure is also not identified. The present pandemic outbreak, COVID-19 started off at Wuhan, China in December 2019 and within a month it reached many countries across the world. However the preventive measures taken were somewhat similar to the previous pandemic. Aim: The aim of the study is to review the pandemic outbreaks in the past century and in the present century. Methodology: Articles were collected from the past 20 years (2000-2020). The Articles were collected from databases like scopus, google scholar and Pubmed and were reviewed based on the output variables. Results and conclusion: Many pandemic diseases were reviewed from the past centuries, some of these diseases caused many deaths and also have caused a huge decline in the country’s economy. Preventive measures were similar for all the diseases except for AIDS and Bubonic Plague