Background: Exercise increases the production of free radicals, while vitamin E acts as a scavenger of free radicals, while vitamin E acts as a scavenger of free- radicals. Thus exogenous vitamin E supplementation has been shown to be effective against exercise- induced oxidative stress.The study aims to investigate the effect of vitamin E (400mg) supplementation on the endogenous antioxidant systems of the body viz. superoxide dismutase (SOD), glutathione peroxidase (GPX) and catalase (CAT) of hundred healthy sedentary females of 18-21 years age group and comparable height and weight.