Abstract: The article describes the results of experimental and clinical application of new compression methods of PSP (Papillosfinkteroplasty), in comparison (in experiment) with the traditional methods of PSP performed by manual interrupted suture. Method: At the same time, in an experiment on corpses and animals, it was noted that the CPSP allows, significantly simplifies, accelerates, standardizes and bloodlessly performs the CPS in comparison with the traditional method of performing this operation, and also creates the most favorable conditions for wound healing, and prevents the development of anastomosis stenosis. Compression PSP in a clinical setting was used in 22 patients operated on for impassability of the terminal part of the common bile duct and Vater's papilla caused by a stone or stenosis of the 2nd and 3rd degree, when this pathology could not be corrected by endoscopic papillosphincterotomy with sanitation of the biliary tract. In the postoperative period, there were no complications associated with the CPSP technique and no lethal outcomes.