Background: Multidetector Computed Tomography (MDCT) is a that advance technology which provides simultaneous acquisition of multiple images during single rotation of X-Ray tubes. There are number of studies which indicates CT with carful physical examination and evaluation of laboratory reports, gives useful diagnostic information of patients with an acute abdomen. Aim and Objectives: To evaluate the accuracy and the impact of early CT diagnosis on management of non-traumatic acute abdomen also wanted to enumerate the various causes of non traumatic acute abdomen. Materials and Methodology: A prospective study was conducted on consecutive patients with acute abdomen in the study for the duration of one year in the department of Radiology. Ultrasonogram was done as the initial modality in these patients and CT was done when USG findings were negative, equivocal or unable to provide additional information. Axial, coronal and sagittal reformatted images were studied. When appropriate, MIP and volume rendering techniques were also analysed. All the patients were followed up before and after CT and also at the time of discharge. Results: In our study male dominance was observed about 74% of the male had acute abdominal pain and whereas females were 26%. Among all 60% of the patients were in the age group of 25 -50 years of age, followed by < 25 years and > 50 years. maximum patients with bowel and disease related to the bowel showed in above table. 26% of the patients had acute appendicitis and each of 19% of the patients had intestinal obstruction and perforative peritonitis. Compared to USG, CT was better in achieving a specific diagnosis. Conclusion : Patients presenting with non-traumatic acute abdominal patient and undergone early CT scan diagnosed and treated accurately which reduced hospital stay and morbidity.