Aim: The purpose of this study is to analyze and compare the properties of Dexmedetomidine with that of Nalbuphine regarding duration of sedation, recovery and adverse effects in short surgical procedures. Materials and methods: It is observational clinical study involving 60 patients belonging to ASA grade 1 & 2 posted for elective minor surgical procedures lasting about 45 -60 minutes, comparison between Dexmedetomidine and Nalbuphine was done and the onset of sedation, duration of sedation and recovery from sedation including adverse effects of both drugs, hemodynamic and respiratory parameters were evaluated. Patients were randomly divided into 2 groups of 30 each .Group N( Nalbuphine) received 50 mcg /kg of Nalbuphine and Group D(Dexmedetomidine) received 1 mcg/kg of Dexmedetomidine over 10 minutes .