ABSTRACT This paper aims to identify the challenges and threats to the information security of cloud computing, which is considered one of the most important technologies in recent decades. Cloud computing provides many virtual services that can be managed and accessed by users through the web and user interfaces. It also enables the users to store their information that can be easily accessed globally. Despite the advantages of cloud computing, there are numerous challenges and threats to the users and service providers that may directly or indirectly affect the cloud computing system as a result affect its information security. Acritical review approach has been adopted as a method to identify the knowledge gaps in the literature. Severalstudiesrelated to the information security challenges of cloud computing have been reviewed and critically evaluated. The critical review approach described in this paper resulted in a set of important information security challenges of cloud computing thatmust betaken into considerationby the users and service providers. Among the most important of these challengesare data encryption, network security, confidentiality, data privacy, malware, Authenticity, databreach, and the challenge of identity and access management.The study recommended the necessity to discover moreinformation security challenges of cloud computing and to take the challenges discussed in this paper into account in order to protect the data and information of the organization and maintain its performance.