Introduction: The Antiphospholipid syndrome (APS) is an autoimmune condition characterized by recurrent arterial or venous thrombosis and/or pregnancy morbidity in the presence of persistently positive circulating antiphospholipid antibodies. Present study was carried out to study incidence of Antiphospholipid antibody syndrome and to study clinicopathologic correlation of APS with special reference to Lupus anticoagulant. Material & Methods: A prospective analysis was performed in 50 patients who were suspected to have Antiphospholipid syndrome as per the diagnostic criteria. Patients with history of thrombosis, recurrent miscarriages, or k/c/o SLE who were suspected of having Antiphospholipid syndrome were included in the study. Results: Out of 50 patients which were included in our study, (24%) were males & (76%) were females. This showed that, there was a female predominance with F: M ratio of 3.16:1. The leading presentation was bad obstetric history (multiple miscarriages, etc.) in (56%) referred cases followed by Deep Vein Thrombosis in (10%) & Portal & splenic vein thrombosis in (10%) cases. (48%) cases showed prolonged aPTT while (52%) were normal aPTT. (32%) were DRVVT positive while (68%) cases were DRVVT negative. Thrombosis was leading presentation in (11.75%) dRVVT positive cases followed by (31.25%) of Bad obstetric history (12.5%) cases were BOH + DVT. Out Of 16 APS patients, (87.50%) cases had Primary APS & (12.50%) cases had Secondary APS. Conclusion: we conclude that any obstetric / thrombotic event should be investigated further by aPTT / dRVVT testing to reduce morbidities associated with the complication.