INTRODUCTION Mental health has taken a toll during this on going pandemic. Emerging research assessing then mental health implications of COVID-19 has identified an increased prevalence of depressive and anxious symptomatology among the general public. The on going second wave has led to a further deterioration of mental health. Studies also showed an increase in prevalence of psychiatric disorders among young adults and also in medical students. AIM: The aim of this study is to identify major stressors associated with the COVID-19 pandemic and to understand their effects on college students’ mental health. METHODS AND MATERIALS: Participants were recruited from the student population of our institute, Sri Lakshmi Narayana institute of medical sciences, Pondicherry. 250 medical students both undergraduate and postgraduate and students of Allied health sciences were included in this study. Pre-final, final and postgraduate students, first year students of the allied health sciences participated in the study. DATA ANALYSIS Demographic variables were expressed using Descriptive statistics. DASS 21 questionnaire items were expressed in frequencies and proportion. Chi-square test was used to test the significance. Analysis was done by using SPSS version 23. P value < 0.05 will be considered as statistically significant. RESULTS Our study results showed only 3 (1.2%) in the mild depression, category, 2(0.8%) were in mild anxiety category and only 1 (0.4%) student was in mild stress. The mean DASS21 score for the 250 participants was 3.0600 (SD 1.797), indicating very few participants were in stress. Stressors and coping skills were studied, there was a statistically significant value for stigma related to COVID-19 and this combined along with stigma due to mental health could have been barriers to seeking help.