This research paper tries to inform about the unfamiliar and lethal outcomes of missing a simple hepatitis B vaccination and being infected with viral diseases. We have tried to compile various symptoms, ways of transmission, preventive measure and progression of hepatitis B. This is a case study of a 32 year old lady who had symptoms of muscle pain joint pain, jaundice and weakness. Her early symptoms were clearly showing association with significant liver disease leading to liver failure due to viral hepatitis B although she had no relevant medical history. Her symptoms progressed rapidlyuntil liver failure and required immediate liver transplant. We present various symptoms, clinical factors that may have influenced her progression to sub-acute liver failure as described in the literature.