Diabetes is a lifelong and long-term disease, which occurs when the pancreas does not produce enough insulin or the body produces insulin but it is not used properly. This leads to an increased concentration of glucose in the blood (hyperglycaemia).Around the globe many lives are frequently affecting through Diabetes. If Diabetes is not treated properly it will lead to lot of complications. If there is excess of glucose in the blood it causes vascular disease, this excess glucose damages the blood vessels also. In Type 1 diabetes body don’t process enough insulin.Type-2 diabetes consists of array of dysfunction characterised by hyperglycaemia or it resists insulin. Hyperglycaemia induces large number of alterations which can result in atherosclerotic legion formation in the arteries and which will lead related conditions of diabetic vasculopathies. Type2 diabetic subjects are particularly at risk for vascular injury; adjunct in many of the subjects, cholesterol and triglyceride levels reach dangerously high levels and accumulate in the lumen of the subject’s vascular system. All over the world about 463 million people are suffering from diabetes according to international diabetes federation. In that 77 million people are belongs to India. 8.7% diabetic population estimated in India in the age group of 20 and 70 years during the year 2020. There are three different types of diabetes namely,Type1,Type2,Gestational diabetes. Major risk factors for diabetes are over weight, obesity. Common signs of diabetes are often urination ,feeling hungry,feeling thirsty,blurry vision,weight loss,numbness in hands,feet.Diabetes is diagnosed by glycated haemoglobin test,random blood sugar test,fasting blood sugar test,oral glucose tolerance test. Total of 20 subjects out of which five persons are healthy or non diabetic persons and the remaining 15 persons are of three categories namely patients with diabetes for less than 10 years, patients with diabetes for greater than 10 years, and patients with neuropathy; each category has five persons participating in this study. This research work focuses at proposing a non-invasive method of screening diabetes using thermoregulation of the peroneal vessel. Since diabetes affects the peroneal vessel of subjects significantly, in this work the thermoregulatory behaviour of peroneal vessel is studied for selected application of hot and cold stress. The study involved 20 subjects, out of which five persons are healthy or non-diabetic persons and the remaining 15 persons are of three categories namely patients with diabetes for less than 10 years, patients with diabetes for greater than 10 years, and patients with neuropathy; each category has five persons participating in this study.The results obtained show the feasibility of disease screening by the proposed method although it is to be improved for further classification of the stages of disease progression and accuracy. From the Diabetes is a lifelong and long-term disease, which occurs when the pancreas does not produce enough insulin or the body produces insulin but it is not used properly. This leads to an increased concentration of glucose in the blood (hyperglycaemia).Around the globe many lives are frequently affecting through Diabetes. If Diabetes is not treated properly it will lead to lot of complications. If there is excess of glucose in the blood it causes vascular disease, this excess glucose damages the blood vessels also. In Type 1 diabetes body don’t process enough insulin.Type-2 diabetes consists of array of dysfunction characterised by hyperglycaemia or it resists insulin. Hyperglycaemia induces large number of alterations which can result in atherosclerotic legion formation in the arteries and which will lead related conditions of diabetic vasculopathies. Type2 diabetic subjects are particularly at risk for vascular injury; adjunct in many of the subjects, cholesterol and triglyceride levels reach dangerously high levels and accumulate in the lumen of the subject’s vascular system. All over the world about 463 million people are suffering from diabetes according to international diabetes federation. In that 77 million people are belongs to India. 8.7% diabetic population estimated in India in the age group of 20 and 70 years during the year 2020. There are three different types of diabetes namely,Type1,Type2,Gestational diabetes. Major risk factors for diabetes are over weight, obesity. Common signs of diabetes are often urination ,feeling hungry,feeling thirsty,blurry vision,weight loss,numbness in hands,feet.Diabetes is diagnosed by glycated haemoglobin test,random blood sugar test,fasting blood sugar test,oral glucose tolerance test. Total of 20 subjects out of which five persons are healthy or non diabetic persons and the remaining 15 persons are of three categories namely patients with diabetes for less than 10 years, patients with diabetes for greater than 10 years, and patients with neuropathy; each category has five persons participating in this study. This research work focuses at proposing a non-invasive method of screening diabetes using thermoregulation of the peroneal vessel. Since diabetes affects the peroneal vessel of subjects significantly, in this work the thermoregulatory behaviour of peroneal vessel is studied for selected application of hot and cold stress. The study involved 20 subjects, out of which five persons are healthy or non-diabetic persons and the remaining 15 persons are of three categories namely patients with diabetes for less than 10 years, patients with diabetes for greater than 10 years, and patients with neuropathy; each category has five persons participating in this study.The results obtained show the feasibility of disease screening by the proposed method although it is to be improved for further classification of the stages of disease progression and accuracy. From the