Background: Aim & Objectives: To study the ABG and electrolyte disturbances in severe malaria. To assess the prognostic significance of these parameters. Materials and Methods: The present study is a prospective study of 50 patients above the age of 12 yrs. The patients were selected from those who were admitted with severe malaria in Acute Medical Care Unit, Ganndhi Hospital, Secunderabad. Patients who came with symptoms or signs of severe malaria like coma, convulsions, hypotension, decreased urine output, anemia, jaundice, respiratory distress are assessed. Out of them who fit the exclusion criteria are excluded.