Abstract: Data from Indonesia Demographic and Health Survey (IDHS) 2017 show the increase on the knowledge of prevention for HIV/AIDS among Women (49%) and married Men (55%). However, the factors that influence the increase of knowledge in the community, especially among eligible women (EW) are still unknown. On the other side, to increase the number of HIV voluntary counselling and testing (VCT) requires a good knowledge from community, so it is important to identify what factors that are related to HIV/AIDS knowledge. Therefore, this study aims to determine the factors associated with HIV/AIDS knowledge among EW. This is a cross-sectional study using secondary data from IDHS 2017 (data couples record). Data were analyzed using the Structural Equation Modelling (SEM). This study analyses the relationship between predisposing, enabling and reinforcing factors with the HIV/AIDS knowledge of EW. The results show that more than 75% of 8.838 EW had less knowledge about HIV/AIDS. There are 73.1% of respondents who have mobile phones, but only 4.9% of respondent access information about HIV / AIDS via the internet. In addition, there are 32.2% of respondents who have an elementary school education level or have no education attainment. From the results of PLS-SEM analysis, it is known that the education level and wealth index of EW are predisposing factors that influence EW’s HIV/AIDS knowledge (pvalue = 0,000). The frequency of reading the newspaper and the possession of mobile phone are the enabling factors that influence EW’s HIV/AIDS knowledge (p-value = 0.025). Meanwhile, the factors of health workers and community meetings are the reinforcing factors related to EW’s HIV/AIDS. Therefore, health promotion is needed to increase the number of women in continuing education, completing secondary education to higher education, and the innovation to use information technology to disseminate information about women's reproductive health to the community.