A common hypertension medication, losartan potassium, is the subject of this investigation, which focuses on the formulation of extended-release tablets containing the medication. According to this inquiry, the release modifiers that were used were xanthan gum and guar gum. Both of these substances are well-known for their capacity to regulate the kinetics of drug release. The extended-release tablet forms of losartan potassium are primarily necessary for the long-acting impact at decreased dose frequency. Losartan potassium is one of the antihypertensive medications that is given to a large number of people and is taken orally. Exploring natural gums, namely xanthan gum and guar gum, as potential drug release modifiers was the primary objective of the current study, which attempted to create and optimize an extended-release tablet containing losartan potassium. A tablet formulation was produced, which was shown to contain all physical qualities within the intended range. Additionally, it demonstrated a sustained release profile, with about 70% of the medication being released over a period of 9 hours.