The evaluation of asymmetry is important for aesthetic and functional evaluation of the maxillofacial region. Aetiology of mandibular asymmetry is multifactorial. Even though there are different techniques available for assessing asymmetry, OPG is relatively inexpensive and one of the most commonly used radiographs. Thus aim of this study was to evaluate the vertical mandibular asymmetry in TMD patients using orthopantomography. The study included OPG’s of 136 patients each in TMD positive and TMD negative group. Condylar asymmetry, ramal asymmetry and total mandibular asymmetry (Condyle + ramus) in vertical plane were assessed. The data was statistically analysed using Mann Whitney U Test. Condylar asymmetry, ramal asymmetry and total mandibular asymmetry (condyle + ramus) was highly prevalent in females of both TMD positive and TMD negative group and it was statistically significant. Condylar asymmetry was highly prevalent in TMD positive group but the results was not statistically significant. No statistically significant difference were found in vertical mandibular asymmetry between TMD positive and TMD negative group. However vertical condylar asymmetry, ramal asymmetry and total mandibular asymmetry was significantly higher females than in males.