Background:Stroke was the second most frequent cause of death worldwide in 2012,accounting for 7.1 million deaths. as data availablefrom Indian subcontinent is scrace in relation to Hyper homocysteinemia as a potential risk factor in ischemic stroke The present study is designed to measure theplasma homocysteine levels in patients presenting with ischemic strokes and correlate with the levels in age and sex matched controls.