Modern teaching methodologies advocate a shift from passive teaching to an active cooperative learning approach as a supplementary teaching approach. Jigsaw methodology advocates a fellow learner group-based teaching style fostering team work based cooperative learning. In the present work, effectiveness of jigsaw teaching method on first year medical students is evaluated on nerve physiology class of first year medical students by a post-test in the form of multiple-choice questions to assess their knowledge and would be compared with the traditional passive method of teaching. The students’ perception about the jigsaw teaching method is also evaluated in the form of a questionnaire, which would include quantitative Likert scale questions and qualitative open-ended comments. The jigsaw method of teaching is overall an effective method for increasing the student-student as well as student-teacher interaction.