Introduction: Acute pancreatitis is a significant cause of morbidity and mortality and is known to run an unpredictable course. Severe pancreatitis occurs in 20%-30% of all patients with acute pancreatitis and is characterized by a protracted clinical course, multiorgan failure, and pancreatic necrosis. Computed Tomography Severity Index (CTSI) andModified Computed Tomography Severity Index (MCTSI) is used as a scoring system in acute pancreatitis. This study aims to correlate the CTSI and MCTSI grading system with patient outcome in terms of organ failure, mortality and duration of hospital stay. Materials and Methods: This was a prospective study conducted for a period of two years. 40 Cases diagnosed as acute pancreatitis were included in this study. These patients underwent contrast enhanced computed tomography (CECT) of the abdomen and pelvis. The findings were recorded as per the CT severity index and modified CT severity index. Results: There was significant correlation between necessity of ICU admission and duration of hospital stay and grade of pancreatitis, positive correlation with duration of ward stay and strong correlation with total duration of hospital stay. Higher CT grade is positively associated with development of local complications and systemic complications. Conclusion: Grading by modified CT severity index has a significant correlation with necessity of ICU admission and total duration of hospital stay. CT severity index and Modified CT severity index can be used to predict the possibility of developing local and systemic complications, the need for interventions and necessity of hospital stay.