Bipolar disorder is predominantly a regular psychological disorder with recurring periods of (hypocritical) mood changes. Past experiments have shown that multiple neuroscience pathways play a crucial role in BD patients' molecular pathogenesis. There is, still, a shortage of specific biomarkers that better detect or forecast patients with BD. The goal of the research is to determine CRP levels in bipolar patients and equate the results of the study with levels of C - reactive protein in safe controls. Moreover, the present thesis also analyzed whether there was a disparity in CRP degree in bipolar disorder (i.e., acute mania, acute depression and asymptomatic patients and maintenance) Patients attended or admitted to TMM&RC TMU in Moradabad obtained this prospective examination. Inclusion requirements and demographic specifications were then recorded. Patients were included. A total of 86 patients included 46 (53.5%) male patients and 40 (46.5%) female patients. The average ño-SD of patients with CRP with bipolar disorder (6.57 ± 4.05) are substantially greater than the mean ± SD of patients with CRP with non-bipolar disorder (2.26 ± 1.53) (P<0.0001) and this analysis shows that C-reactive protein levels was slightly higher than in the patients with bipolar disorders as compared to controls. However, no such substantial correlation of demographic variables was identified in this analysis of bipolar disorder. More validated and accurate results will be collected from further trials of more patients.