In pathological conditions such as Diabetes Mellitus (DM), increased oxidative stress can cause a decrease in endogenous activity in the body so the body is unable to detoxify free radicals that cause cell damage. Some of natural antioxidant sources are moringa leaves (Moringa oleifera Lamk.) and clove flowers (Syzygium aromaticum Merry & Perril). The purpose of this study was to determine the enzyme activity of Superoxide Dismutase (SOD) and Glutathione Peroxidase (GPx) in a mixture composing of ethanol extract of moringa leaf and clove flower towards animals with DM conditions. This research is an experimental laboratory study using a post test only group design. The subjects of this study were 40 white male Wistar rats (Rattus norvegicus) strain which were DM conditioned by streptozotocin induction. Rats were randomly grouped into 8 groups, and each group consisted of 5 rats. The combined dosage of the ethanol extract of moringa leaves and clove flowers used is a combination I : 150: 40 mg / kg body weight rat, combination II 100: 80 mg / kg body weight rat and III 50: 120 mg / kg body weight rat. The results showed that the combination of ethanol extract of moringa leaves (Moringa oleifera L. and clove flower (Syzygium aromaticum Merry & Perril) increased the antioxidant enzyme activity of SOD and GPx in animals with DM conditions.