A reasonable description of what we now call Guillain-Barre' Syndrome (GBS) was offered in 1892 by Osler. The critical features of the illness were not fully synthesized until after the advent of diagnostic lumbar puncture near the end of this century (Osler, 1892). In 1916, Guillain, G and Barre' JA, then French army neurologists and Strohl, Al from England, simultaneously published reports. All adult patients, diagnosed as Guillain-Barre Syndrome, who strictly complied with the NINCDS criteria, admitted to medical college hospital were included in this study. This includes a retrospective study of four years and prospective study of one year. Ninety seven patients entered the study. Data collection was done according to the proforma attached. In retrospective cases, the information was collected from the patient's records. In the prospective group, a detailed history was taken, all patients were examined and then the data collected. Nerve conduction velocities (NCV) were studied in median, ulnar, common peroneal and posterior tibial nerves. Abnormal nerve conduction velocities were found in 46 (98%) of total. Distal latency was prolonged in 47 (100%) patients in the present study.