Orally disintegrating tablet (ODT) of ondansetronis an attractive option for prevention and management of post-operative nausea and vomiting (PONV) compared to intravenous ondansetron. It is given sub-lingually and automatically gets dissolved and hence convenient. There is no need of water and hence it does not interfere with the fasting status of the patients. As it is absorbed by oral mucosa, its bioavailability is high. This is unique thing about ODT of ondansetronand hence attracts its use