Dexmedetomidine hydrochloride is indicated for sedation of initially intubated and mechanically ventilated patients during treatment in an intensive care setting. Dexmedetomidine hydrochloride should be administered by continuous infusion which should not exceed 24 hours. This is an observational prospective clinical study of haemodynamic, ease of intubation and patient comfort of awake fibreoptic intubation under dexmedetomidine sedation in patients posted for elective surgeries under general anaesthesia after obtaining the permission from the Institutional Ethical Committee. During fibreoptic scopy, mean SBP changed from 115.8 mm of hg to 115 mm of hg in group I & 119.4 mm of hg to 113.7 mm of hg in group II. During fibreoptic scopy mean DBP changed from 74.4 mm of hg to 75 mm of hg in group I & 74.5 mm of hg to 74 mm of hg in group II.