Introduction: Postmenopausal osteoporosis is a major health problem in Indian women as it increases chances of both vertebral and non-vertebral fractures. The benefits of the standard treatment regimen for prevention of postmenopausal osteoporosis are not encouraging. Denosumab, in various international studies is found as an effective treatment modality for prevention of postmenopausal osteoporosis. However, there is scarcity of data of Indian postmenopausal women. Therefore, present study is an attempt to observe the treatment effect of denosumab for prevention of postmenopausal osteoporosis. Objective: To observe the treatment effect of denosumab in patients suffering from postmenopausal osteoporosis in terms of bone mineral density(BMD).