Aim: To evaluate the effect of topical Brimonidine 1% in prevention of intraocular pressure spikes after Nd: YAG laser posterior capsulotomy . Materials and Methods: The study was conducted in the outpatient Department of Ophthalmology at GMC Baramulla, over a period of one year from July 2020 to July 2021. It was a prospective, randomized, single blind; placebo controlled study which included post-operative cataract patients with diminished vision, diagnosed as having posterior capsular opacification after uncomplicated cataract surgery and underwent Nd: YAG laser posterior capsulotomy. 190 patients were recruited in our study and divided into two groups of 95 each. Group A received one drop of topical Brimonidine prior to laser and second right after laser. Group B patients received one drop of artificial tears (Lubricant) prior to laser and second right after laser. Follow up was done at one hour , three hours , day one and day three, for intraocular pressure, visual acuity and slit lamp examination