Background:Pre-emptive analgesia is an anti-nociceptive intervention given before incision which helps to reduce pain sensitization to transmission of pain signals evoked by tissue damage.Oxytocin has recently been recognized as an important mediator of endogenous analgesia. The present study aimed to assess the effectiveness of preemptive port site subcutaneous oxytocin infiltration in reducing post-operative pain as compared to post-operative infiltration in patients undergoing laparoscopic surgeries.