A novel coronavirus (nCoV), originating from Wuhan, China had begun as an epidemic in December 2019, declared as a pandemic in March and reiterated the call for countries to go for lock down mode and other strict measures. With the onset of winter, the threat of 2nd wave of infection is looming large over the Northern Hemisphere of the World. Virus is mainly transmitted through droplets and then by touching contaminated surfaces and mucous membranes with the hands. Though the virus survives on environmental surfaces for varied period of time; it gets easily inactivated by biological or chemical disinfectants. Alcohol based disinfectants viz. hand disinfectants, sprayers, mist blowers, cannon, and butterfly sprinklers etc. act as vital component in controlling the pandemic disease. Various biological and physical measures, such as self-disinfectant surfaces, UV-C sterilization, cold plasma technique etc. will assist in disinfecting the surfaces and materials. With unlocking underway, fast disinfection of the office space, meeting room, marketing spaces and even the areas in contaminant zones need quick disinfection through various sprayers, blowers and drones. This review emphasizes on the ongoing efforts to prevent the transmission of COVID-19 and can guide the public health responses, particularly in India.