Abstract: Diagnostics and treatment of genital abnormalities in girls remains relevant to the present day. The greatest scientific interest is uterine and vaginal aplasia. The vast majority of patients with Meier-Rokitans-Kuster-Hauser syndrome are diagnosed in adolescence and older age, as a rule, when complications appear, which worsens the prognosis. The treatment requires adequate psychosocial support of such patients throughout their life with the solution of the reproduction problem.