Background:There are different common treatments for acne vulgaris based on the severity of lesions. In mild cases, topical drugs as topical clindamycin or erythromycin, tretinoin, benzoyl peroxide, and adapalene, and other keratolytic drugs (e.g., alpha-hydroxy acid), salicylic acidcontaining medicine, and/or sulfur or azelaic acid-containing drugs are used. In more severe cases, systemic treatments, such as tetracycline, doxycycline, azithromycin, minocycline, azithromycin, and cotrimoxazole are used. Oral isotretinoin is also administered. In cases with associated hormonal abnormalities, spironolactone and dexamethasone are used.Desloratadine, the active metabolite of loratadine, is a second-generation non-sedating oral antihistamine with proven efficacy and safety in treatment of acne vulgaris. It is squalene-reducing agent, along acting tricyclic antihistamine, anti-inflammatory, mast cell degranulation inhibitor, and has antichemotactic activities against many inflammatory cells, in addition to its sebum regulatory effect