Abstract Background: at a global level and among child bearing age women, the first leading disease burden cause is the depression. Nationally, scarce published data was related to the depression prevalence among pregnant especially with hyperemesis gravidarum women. Aim: to assess the depression extent among hyperemesis gravidarum pregnant Thi-Qarnian women. Methodology: A cross sectional, hospital based, analytical study was carried out in two teaching hospitals (Bent Al Huda and Al Habobi teaching hospitals) in from first week of September /2015 to end of July 2016. All attendants sufferer pregnant from HG to the obstetric outpatients included in this study. Based on previous Iraqi study (37.2%) for of depressive symptoms prevalence in pregnant women sample size had been calculated such prevalence rate with precision of 5%, confidence level of 95%, and added extra sample of 10%, to reach to 322. Beck depression inventory-II (Arabic version) (BDI –II score of > 20 depression was considered) had been used as a specialized questionnaire designed for the achieve the aim of the study. SPSS version 23 had been used for data analysis, P