Abstract: Background: There are various methods of tissue destruction have been employed in the field of oral and maxillofacial surgery like chemicals, irradiation by X-rays and high-frequency electric current and other methods. However any technique in question with the surgeon’s scalpel should be painless, produce minimal damage to the surrounding tissues, should be selective against, for example, malignant cells, it is very much applied locally, promote uneventful healing rapidly and provides good control. Cryosurgery is a therapeutic method of treatment in which inflammation and destruction tissue cells is created by high cold freezing. This review article aimed to throw insight into the efficacy of cryosurgery in the treatment of oral and maxillofacial lesions. Conclusion: With the recent development of better equipment and use of liquid nitrogen, this mode of therapy appears to have promising role in the management of locally aggressive and recurrent lesions in the maxillofacial region. Thus, its ease of application and the absence of postoperative infection, contraction, scarring with little or no recurrence makes cryosurgery a highly useful method in treating various conditions of oral cavity. Cryosurgery procedure can be done in out patient clinic, very much cost feasible and comparatively in treating various oral lesions. It is an less invasive form of therapy when compared to the conventional surgery. Cryoprobes can be used as an adjuvant material with other surgical methods in treating various types of oral lesions. In conclusion there would be a considerable increase in the use of cryotherapy in oral surgery, along with a much better understanding of the basic principles and techniques related to this form of treatment.