Introduction: Hemoglobinopathies are one of the commonest genetic disorders worldwide. They include Thalassemia and abnormal variant hemoglobin such as Hemoglobin S, D, E etc. it is estimated that 7% of the world population carry an abnormal hemoglobin gene. In Hemoglobinopathies recurrent ischemic insults with parenchymal necrosis can result in hepatic fibrosis, chronic liver disease, and cirrhosis. Overall physical status of liver is assessed by liver function test. Material & Methods: Hospital based cross sectional study was conducted involving patients under 18 years of age registered for treatment of haemoglobinathies in the Department of Pediatrics, of Rajendra Institute of Medical Sciences, Ranchi during June 2021 to June 2022. Data was collected by using pretested & predesigned questionnaire. Detailed history of all study participants was taken followed by through clinical examination and laboratory investigation. Result: AST, ALT & ALP levels are significantly higher in patients with fibrosis, male participants affected more compared to female participants and proportion of patients with fibrosis was significantly higher with no. of blood transfusion. Conclusion: Overall positive correlation was observed between increasing stage of fibrosis and level of liver enzymes.