Background information - CA125 is a biomarker that has potential utility across the spectrum: risk assessment, early detection, diagnosis, prognosis, monitoring and therapy. Methods - Patient attending gynecological outpatient department of obstetrics and gynecology,vinayaka mission medical college, Karaikal were screened by history, clinical examination and symptomaticaly for adenaxal massess. Same were screenedwith abdominal and transvaginal sonography to a certain, the pelvic mass arises to theovary. -Clinical history, bimanual examination, Transabdominal ultrasonography was done for all patients fulling inculsion and exclusion criteria. Serum CA125 were acertained by Chemiluminiscent or ELISA. Results - 40 women were selected and evaluated to assess CA 125 and colour Doppler and their sensitivity and specificity in differentiating benign and malignant tumour.Ca125 has sensitivity and specificity of 92.31% and specificity was 70.37% respectively. There was statistically significant difference (P-0.001) in the resistive index and histopathology. The calculated pulsatality index in our study was found to be 96.30% specificity and 92.31% sensitivity. With considering both Resistive index and Pulsatality index the Doppler has sensitivity of 93.3% and specificity of 93%.