ABSTRACT: Background: The Colles' fracture is the most common fracture site in the upper extremity; it causes functional problems and it can result in some disabling complications. Objective: The purpose of this study was to investigate the effect of Low-level laser therapy versus therapeutic ultrasound after Colles' fracture fixation. Method:Fourty patients were assigned randomly into two groups (Group A and Group B) with ages ranged from 18-45ys. Group A consisted of fifteen female patients and five male patients, and received Low-level laser therapy, group B consisted of fifteen female patients and five male patients, and therapeutic ultrasound for 3 times per week for 6 weeks. Patients were evaluated pre and posttreatment for the function of the wrist joint, grip strength, and wrist joint's ROM. Results:When comparing patients in group (A) who received LASER therapy, and patients in group B who received Therapeutic ultrasound, we observed clinical difference but it was only statistically significant in favor of group (A) patients in terms of pain and function. Group (A) had a better score in functional disability but it was statistically significant, also had a better score in grip strength but it was not statistically significant. However group (B) had better scores in the range of motion of flexion, extension, radial deviation, and ulnar deviation but it was not statistically significant and also had lower scores in the patient-reported in grip strength. Conclusion: It can be concluded that both Low-level laser therapy and therapeutic ultrasound after Colles' fractures fixation improved pain, patient hand function, grip strength, and range of motion. Both of similar degrees of improvement, however low-level laser therapy had more improvements than therapeutic ultrasound in the wrist pain and function.