Aim: The aim of the study was to compare the demineralization potential of different luting cements used for bands in space maintainers. Method: A total of 120 caries free extracted permanent molars were collected and randomly divided into four groups, each group containing 30 samples. Stainless steel preformed orthodontic bands were cemented on teeth in each group as follows. Control group (nonbanded non-cemented), Conventional glass ionomer cement (GIC), Resin-modified glass ionomer cement (RMGIC) and Adhesive resin. Later all the samples were demeneralised in acidic solution followed by imulsion in methylene blue dye. Evaluation of created demineralization through dye penetration was done. Statistical analysis was performed to determine the significant differences between the groups. Results: The highest demineralization depth was seen with control group followed by adhesive resin, conventional GIC and RMGIC. On intergroup comparison, all values were found to be statistically significant. Conclusion: RMGIC can be recommended as an effective luting cement for cementation of bands because it showed least depth of demineralization than the other groups.