The prevalence of PJI in primary hip and knee procedures is estimated to be between 0.5% and 3%[1]. Coagulase-negative staphylococci (CoNS) are biofilm-producing pathogens whose role in periprosthetic joint infection (PJI) is increasing. These are a heterogeneous group of microorganisms that do not promote blood clot formation because, unlike Staphylococcus aureus, they do not produce the enzyme coagulase [2]. CoNS was classically grouped together to distinguish it from S. aureus and because they were considered to be less pathogenic [3].Subsequently, they have been identified as one of the most common causes of PJI, with a reported incidence that is increasing [4, 5, 6]. In addition, there is increasing evidence of mutability, antibiotic resistance, and robust biofilm production by this bacterial class [7].