Background: Chronic myelogenous leukaemia is one of the common leukaemia seen with a proper understanding of the leukemogenic pathway which led to best treatment options as compared to other leukaemia’s. Many aspects of the neoplasm are yet to be discovered in the light of current development in the investigation particularly molecular testing. The present study was under taken to find out the actual burden of the disease along with the estimating the prevalence of chronic myeloid leukemia in patients coming to IGIMS Patna as most of the patients usually present in the late stage of disease.