ABSTRACT Pulmonary Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis. TB cases in Indonesia reached more than 300 per 100.000 populations meanwhile in Jakarta as many 24.775 cases, for East Jakarta as many 7.520 cases. Properly diagnose, and the granting of anti-tuberculosis drugs as well as monitoring of side effects are expected to reduce the number of TB incidence. The research aims to know the characteristic and side effects of anti-tuberculosis drugs against TB patients who were hospitalized in UKI Hospitalon January 2015 – September 2017. The method used is content analysis document that is retrospective with 212 populations. The research results obtained that most patients are male, age group 45 - 54, the level of education is senior high school, entrepreneurs, and has lived in Jatinegara. The most clinical manifestation of TB is cough and in the physical examination is vesicular sound with Ronchi (rales or crackles). The most work up of TB is x-ray and LED.Meanwhile, BTA examination only 40% with the most result is BTA positive. The most imaging of x-ray is infiltrating. The most prescribed is FDC. The distribution of adverse effect due to these drugs is the same (one each)