This article we discussed about biochemical changes in blood hemophilia A is a worldwide disorder of the coagulation system. It is a male disease, but women with hemophilia are less common in communities with high levels of kinship. There are steps to achieve an optimum life for patients with hemophilia in developing countries, and awareness of the pattern of death in patients with hemophilia is a prerequisite for any health-care program. Owing to the lack of any data on the pattern of death in patients with hemophilia from developing countries, the current study was done to address common causes of death, and the spectrum of causes of death among individuals with hemophilia A and B.