Situs inversus totalis is rare condition with which one can live their life without any complications. Hence the diagnosis of the condition is usually incidental. The diagnosis of cholelithiasis in such patients in whom the underlying situs inversus has not been brought to light is not straight forward as the presenting complaint is usually on the opposite side. The management principles of cholelithiasis are the same as for a normal individual. The critical part of the management lies in the fact that conventional laparoscopic cholecystectomy, which is the definitive treatment of cholelithiasis, is suited for right handed surgeons for a gall bladder which is located in the right hypochondriac region. Since the gall bladder is located in the opposite side in above condition, safely carrying out the procedure has several challenges. This case report details the challenges faced in one such case of laparoscopic cholecystectomy in a case of situs inversus totalis