Abstract Aim: The aim of this study is to do a review on celiac diseases and the interlink between celiac diseases and depression. Introduction: Celiac disease is an autoimmune disease which is triggered due to the exposure of dietary gluten in genetically susceptible individuals. Often, celiac disease can be associated with depression and many other health disorders. Previous studies have shown that a lifetime depressive symptoms can occur in one third of the celiac patients. Celiac disease can develop at any age. Since celiac disease is an autoimmune disorder, it is associated with other autoimmune disorders. If left untreated, celiac disease can lead to additional serious health problems. Celiac diseases can be treated by natural methods like consuming gluten free food, healing of intestines with aloe vera , paprika, dietary supplements, nutrients etc. The main therapeutic intervention of celiac disease is a gluten-free diet but however now the dietary agents are under active investigation. Methods : The present study has collected various articles related to the current topic from various internet sources such as PubMed, Google Scholar, PMC, etc..The articles were reviewed between the period 2000 to 2020. Conclusion: Thus healthcare professionals need to be aware of these ongoing psychological burdens of celiac disease and support patience and recommend a gluten-free diet. This study emphasises whether celiac disease is associated with depression.