INTRODUCTION: The science of Ayurveda originated with the intention of “Swasthasya Swasthya Rakshanam, Aturasya Vikara Prashamanam” i.e Maintaining the normal health status of body and curing the diseased. Several signs and symptoms in an individual indicate different diseases. Thorough examination of patients not only help physician to diagnose the disease but also help in planning the treatment as well as predicting the prognosis.In Ayurveda Prameha is usually correlated with Diabetes Mellitus with important symptoms like Prabhoota Mutrata i.e Increased frequency and quantity of urine and Avila Mutrata which means turbid urine. Prameha is considered as Chirakaaleena vyadhi (chronic disease) which is Anushangi1 (recurring) in nature. It is due to vitiation of tridoshas (vata-pitta-kapha) especially Kapha dosha which can be considered as important components of protoplasm2 which governs all the activities of body and also symbolizes the physico-biological properties of compounds made through a different combination of Panchamahabhootas i.e Akasha (space), Vayu (electrons), Teja (energy), Jala (proton) and Prithvi (neutron)3 . The signs and symptoms which herald the oncoming death, the signs and symptoms indicating near fatality are called as Arista lakshanas. Knowledge of this Arista is very important in treatment because one should have proper knowledge regarding the Ayu(life span) of the individual only then the treatment becomes successful. If physician tries to treat patients with Arista lakshanas then it will affect his/her Dhana (Money/Property), Yasha (Success/fame) and also Vidhya (Knowledge). AIM & OBJECTIVE: To understand the basic concept of certain Arista lakshanas in Ayurveda To analyze Arista lakshanas in Prameha METHODOLOGY: Literary review from Ayurveda classical and contemporary texts, text books of Modern medicine, Review articles & Journals and other Internet sources. OBSERVATION & RESULT: Arista (Fatal signs & symptoms) explained in Ayurveda proves the Yukti (intellectual capacity) of our Acharyas during those days were even without any developed technological support several discoveries were done. This was possible only by keen interest in learning human body. It paved a way for developing such a scientific understanding of Arista (Fatality) which still proves to be right. CONCLUSION: It can be concluded that drastic improvement in technology and medicine helped us in earlier recognition of symptoms in a disease and to convert previously explained majority of fatal signs and symptoms as curable or manageable now.