Background:schizophrenia is a chronic disease which has an impact on patient`s health and quality of life. This is occurred by negative symptoms of the disease, accompanied withpoor lifestyle, and under the side effects of antipsychotics, which varied from poor diet, low energy, increase weight to comorbid metabolic syndrome. Previous researchers had found a correlation between the impact of disease and medications on adherence to treatment, which in return worse the prognosis. The goal was to find out if modification of lifestyle among schizophrenia patients may affect the side effects of anti-psychotics, including metabolic syndrome or one of its criteria. Methods: 36 patients had been selected randomly and underwent program of modifying lifestyle for 3 months and assessment of side effects of anti-psychotics by using Glascow anti-psychotics side effects scale (GASS) ,Morisky scale for assessment of adherence to treatment and Health Promoting Lifestyle Profile II( HPLPII ) scalefor quality of life. Results: patients with schizophrenia had shown after applying lifestyle modification program a significant improvement in all dimension of HPLP II scale from the first month except for health responsibility, Spiritual growth and Interpersonal relations subscales which started to show significant improvement from the second month, with high significant increase in morisky score after 3 months of life style modification and improvement in total GASS scale after the second months of commitment of lifestyle modification with significant improvement in all dimension except for cardiovascular and diabetes. Conclusion: When patients underwent lifestyle modification, there was a significant improvement appeared on GASS Scale results, that showed decrease in side effects of antipsychotic. Meanwhile, morisky scale showed significant improvement in rate f adherence to the treatment at the end of study and in HPLPII scale results indicated to have better quality of life