Introduction: Asthma, one of the most common chronic diseases, is characterised by symptoms of random airway blockage and has a range of overlapping phenotypes1. A crucial part of both health and sickness is played by ADAM33, a disintegrin and metalloproteinase glycoprotein engaged in intercellular and cell-matrix interactions.These proteins play a role in myogenesis, neurogenesis, the inflammatory response, and apoptosis in healthy individuals. They do this via altering cell adhesion and cell signalling or through proteolysis. It's significant that the airway epithelium also contains the ADAM33 protein, in addition to the smooth muscle and mesenchymal cells. Oxidative stress may have a role in the aetiology of asthma, a condition that affects the airways and is chronically inflammatory. Acute and chronic inflammation-related features of the airways in asthma include thickening of the airway wall, subepithelial fibrosis, and increased smooth muscle mass. These changes are linked to airway remodelling and may contribute to the development of airflow limitation by increasing airway resistance. Materials and Methods: The study was conducted in 100 patients (70 asthmatic and 30 normal) at GK labs Srinagar Jammu and Kashmir after taking proper consent. BALF was obtained from fibre-optic bronchoscopy. Samples were clarified by centrifugation, and the supernatants were stored at -80°C until required for the measurement of ADAM33 protein activity. 3 mL of blood was collected for the measurement of oxidative stress biomarkers (Lipid peroxides assay, Plasma protein carbonyls). Results and conclusion: In this study, we found that there is an increase in the biomarkers for oxidative stress and activity of ADAM33 protein in asthmatic patients.