Background: Emergency conditions involving the gallbladder and the bile ducts are common radiological challenging problems.The present study was conducted to assess diseases of gall bladder using USG. Materials & Methods: 60 patients of gall bladder disease of both genders underwent USG performed with a3.5-5 MHz probeby scanning in subtotal position. Once the gallbladder was clearly identified, longitudinal and transverse views of the gallbladder was obtained. Results: Out of 60 patients, males were 38 and females were 22. Common pathologies were polyps in 32, benign tumor in 14, cholecystitis in 10 and gall stones with sludge in 4 patients. The difference was significant (P< 0.05). Conclusion: Authors found that ultrasound is non-invasive and the least expensive imaging modality for the assessment of the gallbladder diseases. Common pathologies were polyps, benign tumor, cholecystitis and gall stones with sludge.