Background: Antimicrobial resistance is now an emerging global threat and there is an upsurge of multidrug resistant bacteria. As general population plays a major role in use and abuse of antibiotics, their knowledge and practice regarding antimicrobials needs proper assessment. Method: This was a cross sectional study among 250 participants among age group 18 – 60 years. Results: Results showed that 34% felt that antibiotics can cure viral infections and 32% would discontinue antibiotic course in midway. 34% of responders would purchase antibiotics over the counter without prescriptions and 26% would use the leftover antibiotics. Conclusions: There is a wide gap in knowledge in antibiotic usage and attitude among responders regarding antibiotic usage. This can be filled by educating the public about usage and hazards of antimicrobial drug resistance by incorporating it in school curriculum and conducting awareness programme through various media.