Aims and Objective: The aim of present study was to study and compare alterations in liver function tests and gamma glutamyl transferase in laparoscopic cholecystectomy. Material and Method: It is a prospective study conducted in the department of General Surgery at Maharishi Markandeshwar Medical College and Hospital Kumarhatti, Solan from April 2021 to April 2022 and included 50 cases diagnosed with cholelithiasis. LFTs and GGT was done 24 hour before, 24 and 72 hours after the laparoscopic cholecystectomy. An informed and valid consent from the patients were taken to include in the present study. The data collected was analysed by students paired t-test.