Background:After Covid-19 Pandemic, there are many elements including academic stress that contribute to psychological problems among medical students. Most importantly, these psychological elements may have an impact on how satisfied they are with their academic success.Aim and Objectives:To study the association between academic stress and academic self-efficacy on academic performance among MBBS and nursing students in the postCOVID-19 pandemic.Methodology:This is a cross‑sectional study and it was conducted via Google Form survey completed by students studying MBBS and nursing students in Erode district.A self-report format was used to collect data from students regarding academic stress, academic self-efficacy, and academic performance.Results:A total of 295 students(33.9% male, 66.1% female) had completed survey. MBBS and nursing students had a moderate level of academic self-efficacy (69.9%), a high level of academic stress.Students' academic stress, self-efficacy, and academic performance were found to be positively correlated (p < .05). The results show that significantly MBBS students‘ academic self-efficacy mean score significantly higher than Nursing students (P <0.05). Conclusion:There is a significant association was observed on the levels of Academic Self efficacy versus MBBS and Nursing course students (P<0.05).