Homesickness is the mental and physical distress caused by the anticipated separation of students from their families. This homesickness may lead to depression, stress, and other psychological problems. The objective of this study is to observe the post-vacation mental state of the students who have been suffering from homesickness in the hostel. In this study, a standardized tool that measures the level of anxiety of the students was used. A questionnaire DASS-21 (Depression Anxiety Stress Scale), containing 21 questions was used which was circulated among 100 -1st-year dental students of Saveetha Dental College who were affected by homesickness. Data collection was done through the administration of Google forms and the data were analyzed in SPSS version-15 using cumulative frequency and percentage analysis. The results of the study showed that the post-vacation period had considerable changes in the student population. The students developed a feeling of positivity, had good energy levels and they were not stressed and anxious and felt enthusiastic during the post-vacation period. Thus the present study concludes that physical and mental stress disorders can only be reduced by spending time with family and home place.