Background Cardiac rehabilitation is the restoration of a person to optimal state of function in 6 areas; physiologic, Mental, Spiritual, Economic and Vocational. Objectives: To assess the level of knowledge of staff nurses regarding cardiac rehabilitation.To evaluate the effectiveness of structured teaching programme (STP) on knowledge regarding cardiac rehabilitation program.To find out the relationship between the Pre-test knowledge score and Post-test knowledge scores Material & Methods: An evaluative approach and one group pre test post test design was used to evaluate the knowledge regarding cardiac rehabilitation program among staff nurses in selected hospitals, Karad. The study was carried out in Krishna Hoapital & Medical Research Center, Karad and 60 staff nurses were selected by non probability purposive sampling technique. statistics. Reliability of the tool was tested and validity was ensured in consultation with guides and experts in the fields of medicine and nursing